ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS

listed in Appendix V. 4.9 Overdose ... acid substitutions in the Fc regions, to extend antibody half-life and to reduce antibody effector ... bind to spike with equilibrium dissociation constants of KD= 2.76pM, 13.0pM and 13.7pM, respectively, blocking its interaction with the human ACE2 receptor, resulting in a blockade of virus

  Constant, Appendix, Acid, Dissociation, Dissociation constant