Reference ID: 4145755 - accessdata.fda.gov

C), in patients with creatinine clearance less than 60 mL/minute, in cytochrome P450 2D6 (CYP2D6) poor metabolizers, and with concomitant use with strong CYP2D6 inhibitors.

  Cytochromes, P450, Cytochrome p450

HIGHLIGHTS OF PRESCRIBING INFORMATION Ulcerative …

Increased risk of serious infections leading to hospitalization or death, including tuberculosis (TB), bacterial sepsis, invasive fungal infections (such as histoplasmosis) and infections due to other