HYPOCELLULAR BONE MARROW… WHAT’S NEXT?

DNA damage response pathway 1. CORE COMPLEX: 8 wild type proteins ‘FANC’ (A,B,C,E,F,G,L,M) and 4 additional proteins FAAP (16,20,24,100) 2. ID COMPLEX: two downstream proteins FANC I and D2 3. DOWNSTREAM EFFECTOR COMPLEX: 5 other proteins: FANCD1, BRCA2, FANCJ, BACH1, and BRIP1 21 known FA subtypes 1 •Mutation of …