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Clinical Guidelines ACP

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Current Pharmacologic Treatment of Dementia: A Clinical PracticeGuideline from the American College of Physicians and the AmericanAcademy of Family PhysiciansAmir Qaseem, MD, PhD, MHA; Vincenza Snow, MD; J. Thomas Cross Jr., MD, MPH; Mary Ann Forciea, MD; Robert Hopkins Jr., MD;Paul Shekelle, MD, PhD; Alan Adelman, MD; David Mehr, MD, MS; Kenneth Schellhase, MD, MPH; Doug Campos-Outcalt, MD, MPA;Pasqualina Santaguida, PhD; Douglas K. Owens, MD, MS; and the Joint American College of Physicians/American Academy of FamilyPhysicians Panel on Dementia*Description:The American College of Physicians and AmericanAcademy of Family Physicians developed this guideline to presentthe available evidence on current pharmacologic treatmentof :The targeted literature search included evidence relatedto the effectiveness of 5 Food and Drug Administration approved pharmacologic therapies for dementia for outcomes inthe domains of cognition, global function, behavior/mood,andquality of life/activities of daily 1:Clinicians should base the decision to initiatea trial of therapy with a cholinesterase inhibitor or memantine onindividualized assessment.

Current Pharmacologic Treatment of Dementia Clinical Guidelines www.annals.org 4 March 2008 Annals of Internal Medicine Volume 148 • Number 5 371 24, 26, 27), 52 to 54 weeks (4, 5), 156 weeks ...

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