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The science behind 23andMe's Type 2 Diabetes report White Paper 23-19 The science behind 23andMe's Type 2 Diabetes report Estimating the likelihood of developing type 2 diabetes with polygenic models Authors: Michael L. Multhaup*, Ryo Kita*, Becca Krock, Nicholas Eriksson, Pierre Fontanillas, Stella Aslibekyan, Liana Del Gobbo, Janie F. Shelton, Ruth I. Tennen, Alisa Lehman, Nicholas A. Furlotte, and Bertram L. Koelsch *these authors contributed equally to this work Updated April 2019; see the "Change Log" section for more details.

Th e s c i e n c e b e h i n d 2 3 a n dM e 's Typ e 2 D i a b e t e s re p o rt GLP-1 analogs (Astrup et al. 2012), have been shown to reduce the risk of progression from

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