ISPAD Clinical Practice Consensus Guidelines 2018 ...

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ISPAD Clinical Practice Consensus GUIDELINESISPAD Clinical Practice Consensus Guidelines 2018: Diabeticketoacidosis and the hyperglycemic hyperosmolar stateJoseph I. Wolfsdorf1| Nicole Glaser2| Michael Agus1,3| Maria Fritsch4|Ragnar Hanas5| Arleta Rewers6| Mark A. Sperling7| Ethel Codner81Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts2Department of Pediatrics, Section of Endocrinology, University of California, Davis School of Medicine, Sacramento, California3Division of Critical Care Medicine, Boston Children's Hospital, Boston, Massachusetts4Department of Pediatric and Adolescent Medicine, Medical University of Vienna, Vienna, Austria5Department of Pediatrics, NU Hospital Group, Uddevalla and Sahlgrenska Academy, Gothenburg University, Uddevalla, Sweden6Department of Pediatrics, School of Medicine, University of Colorado, Aurora, Colorado7Division of Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York8Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago.

antidiuretic hormone (ADH) in response to hyperosmolality (which increases blood pressure via V2 receptors), increased osmotic pres-sure from marked hyperglycemia, or other factors.6 Considerable urine output persists because of glucosuria until extreme volume

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