LSGE
Approach to a high ferritin level: the hepatologist s perspectiveAmer El-Sayed, day, LSGEMay 28, 2011FERRITIN Major storage protein for iron Present in large amounts in macrophages and hepatocytes (storage) In erythroblasts (for metabolic purposes) Small concentrations in plasma (not transport protein like transferrin) reflects total iron body stores Most widely used surrogate for iron overload (highly sensitive in Hemochromatosis), low : etiology Increased ferritin synthesisAcquired or genetic conditions, with or without iron overload Increased ferritin releaseFrom damaged cells: steatosis, steatohepatitis, chronic viral hepatitis, liver necrosis, acute hepatitis, acute MI, splenic infarct Clue: clinical settingHYPERFERRITINEMIA: etiologyIron overload Primary: Hereditary hemochromatosis Hereditary aceruloplasminemia Secondary: Transfusion overload Excess dietary iron Porphyria cutanea tarda Cutaneous photosensitivity Hepatic iro
The LSGE is a scientific society of medical doctors who are interested in the function and diseases of the gastro- intestinal tract. The aim of the Society
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