Objectives 자기공명영상을이용한확산 …

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1KSMRM Spring 2007 KSMRM Spring 2007Objectives . . .KSMRM Spring 2007Content Perfusion( ) MRI Dynamic Contrast Enhanced (bolus passage) Dynamic Susceptibility Contrast (bolus tracking) Arterial spin labeling Diffusion( ) MRI Diffusion-weighted imaging Diffusion tensor imaging Fiber TrackingKSMRM Spring 2007pMRI: DCE or T1W PWI Common outputs: EES volume, CBF, CBV, Ktrans GD-DTPA : -> blood plasma : BBB (blood brain barrier) Tumor multiple sclerosis (MS) EES(Extravascular Extracellular Space ) . T1 T1 KSMRM Spring 2007DCE: New Parameters constant rate: kep=PS/ve Transfer constant (Ktrans): BBB leakage PS flow permeability Limited permeability model (ex, MS): Ktrans=PS (flow>>PS) Limited flow model (ex, tumor): Ktrans=flow (flow<<PS) Permeability Map free software: LUPE programKSMRM Spring 2007Problems of the DCE Method Protocol: 3D Fast GE T1W sequenc

3 KSMRM Spring 2007 KSMRM Spring 2007 Deconvolutionand Data Presentations • Hematocrit양의차이의보정: 일정상수로처리 • Dispersion에대한flow 값의오차가발생