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Pharmaceutical Compounding and Dispensing Sample Chapter

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6SolutionsIntroduction and overview101General principles of solution preparation103Solubility103Stability103G eneral method103Oral solutions104Elixirs104Linctuses105Syrups 105Mixtures105Draughts105Spirits105Paedi atric drops105Gargles and mouthwashes105Enemas and douches105External solutions105Lotions105Liniments105Applic ations105Collodions106Worked examples106Summary of essential principles relatingto solutions112Packaging112Discard dates112Labelling113Introduction and overviewSolutions are one of the oldest dosage forms used in thetreatment of patients and afford rapid and highabsorption of soluble medicinal products. Therefore,the Compounding of solutions retains an importantplace in therapeutics today. Owing to the simplicityand hence the speed of preparation of an ad hoc for-mulation, they are of particular use for individualswho have difficulty in swallowing solid dosage forms(for example paediatric, geriatric, intensive care andpsychiatric patients), where compliance needs to bechecked on administration (for example in prisons orpsychiatric pharmacy) and in cases

(see Chapter 5, page 70). 4 Prepare a suitable label (see Chapter 5, page 91). 5 Weigh all solids. 6 Identify the soluble solids and calculate the quantity of vehicle required to fully dissolve the solids. If more than one solid is to be dissolved, Box 6.1 Advantages and disadvantages of solutions as dosage forms Advantages Disadvantages

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