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Steroidogenic Pathways - GDX

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3 HSD3 HSD17,20 Lyase17,20 LyaseCYP2117-hydroxylase17-hydroxylaseCY P21CYP11b15 5 5 11 HSD3 HSD3 HSDCOMTCOMT17 HSD3A41A15 3 HSD17 HSD1B117 HSD5 5 17 HSDAromatase (CYP19)Aromatase (CYP19)11-DeoxycortisolCorticosteronePre gnanediolPregnanetriola-THFTHFTHE2-MeO(E 1+E2)2-OH(E1+E2)16a-OHE14-OH(E1+E2)4-MeO (E1+E2)EtiocholanoloneAndrosteroneAndros tanediolCholesterolPregnenoloneProgester one17-OH-Progesterone17-OH-PregnenoloneA ndrostenedioneDHEAAndrostenediolEstrone (E1)Estriol (E3)Estradiol (E2)DHTTestosteroneCortisol(active)(inac tive)CortisoneCongenital adrenal hyperplasia (CAH), smoking, E2, progesterone, azole antifungals, spironolactoneCrucifers, berries, I3C, DIM, soy, flaxseed, caffeine, rosemary, exercise, thyroxineExcess sugar or n6 fats, cimetidine, OCPsHypothyroidism, pesticide exposure, sm

GSH; reduce stress, rule out Hg toxicity & oxidative stress Hyperglycemia, azole antifungals , aging smoking dioxin toxicity, HIV , licorice, etomidate , liarozole PCB toxicity, DHEA, antiepileptics Licorice Insulin resistance, obesity, fatty liver, nonalcoholic steatohepatitis Phytoestrogens flaxseed progestins tamoxifen More cortisol: Obesity ...

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