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SUGI 27: Generating Randomization Schedules …

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Paper 267-27Generating Randomization Schedules Using SAS ProgrammingChunqin Deng and Julia Graz, PPD, Inc., Research Triangle Park, North CarolinaABSTRACTRandomization as a method of experimental control hasbeen extensively used in clinical trials. Generating therandomization schedule has been an essential part ofsome trials. We discuss how to use SAS programmingand SAS PROC PLAN to generate the randomizationschedule. The issues related to Randomization are alsodiscussed. Case studies are used to illustrate the use ofSAS programming and SAS PROC PLAN in generatingrandomization : Randomization Schedule, clinical Trial,PROC PLANINTRODUCTIONRandomization as a method of experimental control hasbeen extensively used in clinical trials. The fundamentaloccasion for Randomization is the assignment oftreatment conditions to patients or, as preferred herein,assignment of patients to treatment tends to produce treatment groups inwhich the distributions of prognostic factors, known andunknown, are similar.

CASE STUDY 3: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-ESCALATED, GENDER-MATCHED STUDY Case study 3 is a phase I clinical

  Phases, Clinical, Generating, Randomization, Generating randomization

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