腸泌素在第二型糖尿病治療的角色 - tsim.org.tw
2011 22 401-408. . . . . (incretin) (glucagon-like peptide 1 . GLP-1) (distal ileum) (colon) . GLP-1 ( cells) . (insulin) ( cells) (glucagon) . GLP-1 . GLP-1 (gastric emptying) . (satiety sensation) . GLP-1 -4 (dipeptidyl peptidase 4 DPP-4) . . (incretin action) DPP-4 (incretin mimetics) DPP-4 (DPP-4 inhibitor) . . (Incretin). (Glucagon-like peptide 1 GLP-1). -4 (Dipeptidyl peptidase 4 DPP-4). . 3 . 1960 . 1902 Bayliss Starling . (duodenum) . (jejunum) . 1. . . 2. (incretin) . (incretin effect)4 . 100 1 . 402 . - (entero-insular axis) L (open- 1970 (gastric inhibitory peptide type endocrine cells) . glucose-dependent insulinotropic polypeptide (apical surface) . GIP) . (basolateral surface) . GIP . . 1983 proglucagon (acetylcholine) . . (glucagon-like peptide 1 (gastrin-releasing peptide) (leptin) . 5. GLP-1) GLP-1 (insulin) . GIP GLP-1 (somatostatin) 12.
腸泌素在第二型糖尿病治療的角色 403 dependent insulin secretion)18，因此比較不會發 生胰島素過度分泌所引起之低血糖。此外， 動物實驗顯示腸泌素也有幫助胰臟β cells增生
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