Understanding Diagnostic Tests - …

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11/9/20101Understanding Diagnostic TestsSteven M. Horwitz AttendingLymphoma ServiceMemorial Sloan-Kettering Cancer CenterLymphomasDiagnosis and workup 2 of the most important initial questions What do you have? Where do you have it? Other important question What are you going to do about it?11/9/20102LymphomasDiagnosis biopsy of suspicious lymph nodes or masses (extranodal) Routine histology Immunophenotyping CD2, CD3,CD4, CD5, CD7, CD8, CD20, CD30, CD56, etc11/9/20103Large CellsSmall CellsFollicularDiffuseArchitecture11/9/2 0104Types of Biopsies Fine needle aspirate (FNA) Core needle biopsy Surgical: Incisional or excisionalTypes of BiopsiesFNASmallest sampleBedside or hard to reachNo ArchitectureCoreHollow needleLess invasiveCT guidedSmall SampleSurgicalBest sampleMost informationMost tissueRequires an incision11/9/20105Immunophenot

11/9/2010 4 Types of Biopsies Fine needle aspirate (FNA) Core Needle Biopsy Surgical: Incisional or excisional Types of Biopsies FNA Smallest sample Bedside or hard to reach No Architecture Core Hollow needle Less invasive CT guided

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