Review p53 protein function, structure, and regulation ...

several domains. At the N-terminal, there are two distinct transactivation domains (TADI and TADII), a nuclear export signal (NES) followed by the proline-rich domain (PD) and the DNA binding domain (DBD) (Wang et al., 1994). The TADI (residues 1–42) and TADII (residues 43–62) are critical for p53 regulation as

  Binding, Domain, Dna binding

Mechanisms of Toxicity

Trimerization of the receptor death domains allows binding and activation of FADD (Fas-associated death domain protein) and formation of death-inducing signaling complex (DISC), which recruits and activates procaspase 8 and 10 to caspase 8 and 10.

  Binding, Toxicity, Mechanisms, Domain, Mechanisms of toxicity

タンパク質配列のデータベース

one or more domains/repeats in common. A InterPro entry of type=family may contain a signature for a small conserved region that is representative of the family, and need therefore not necessarily cover the whole protein. An InterPro domain is an independent structural unit which can be found alone or in conjunction with other domains or repeats.

  Domain

THE J B C © 2000 by The American Society for Biochemistry ...

homology with the BH1, BH2, and BH3 domains of other Bcl-2 family proteins (Fig. 1). Overall, the sequence of this protein was most similar to rat Bok, a pro-apoptotic Bcl-2 family mem-ber, with 30% sequence identity (52% similarity). The homol-ogy of DBok to other Bcl-2 family proteins was further analyzed

  Domain

Lecture 7 Protein-Protein Interaction

the DNA-binding domain (DB: blue circle) and one that contains an activation domain (AD: half blue circle), are co-transfected into an appropriate host strain. (C) If the fusion partners (yellow and red) interact, the DB and AD are brought into proximity and can activate transcription of reporter genes (here LacZ).

  Binding

Oxford Cambridge and RSA AS Level Biology A

22 Even the smallest DNA molecules are very long. • A kilobase (Kb) is a unit equivalent to 1000 base pairs of a DNA molecule. • One Kb of double stranded DNA has a length of 0.34 µm. (a) The DNA in the nucleus of a cell from a fruit fly (Drosophila) is 5.6 cm long. (i) Calculate the number of Kb in the DNA of the fruit fly. Show your working.