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122 Myasthenia Gravis - FRCA

ANAESTHESIA AND Myasthenia Gravis . ANAESTHESIA TUTORIAL OF THE WEEK 122. 15TH DECEMBER 2008. Dr Arnab Banerjee Hospital Luton & Dunstable Hospital NHS Trust Correspondence to INTRODUCTION. Myasthenia Gravis (MG) is an autoimmune disease characterized by weakness and fatigability of skeletal muscles, with improvement following rest. It may be localized to specific muscle groups or more generalized. MG is caused by a decrease in the numbers of postsynaptic acetylcholine receptors at the neuromuscular junction, which decreases the capacity of the neuromuscular end-plate to transmit the nerve signal. Initially, in response to a stimulus resulting in depolarization, acetylcholine is released presynaptically which results in a muscle action potential being generated. In MG, the number of activated postsynaptic receptors may be insufficient to trigger a muscle action potential.

DIAGNOSIS Laboratory tests.None are available in a time frame that is useful to confirm the emergency diagnosis of myasthenia gravis (MG). An arterial blood gas determination can

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  Diagnosis, Myasthenia, Gravis, Myasthenia gravis

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