2.3. IDENTIFICATION - DrugFuture

EUROPEAN PHARMACOPOEIA IDENTIFICATION reactions of ions and functional IDENTIFICATION01/2008 IDENTIFICATION REACTIONS OFIONS AND FUNCTIONAL GROUPSACETATESa) Heat the substance to be examined with an equal quantity ofoxalic acid R. Acid vapours with the characteristic odour ofacetic acid are liberated, showing an acid reaction ( ).b) Dissolve about 30 mg of the substance to be examined in3mLofwater Ror use 3 mL of the prescribed solution. Addsuccessively mL oflanthanum nitrate solution R, M iodineand mL ofdilute ammonia to boiling. Within a few minutes a blue precipitate isformed or a dark blue colour a test-tube about 180 mm long and 18 mm in externaldiameter, place about 15 mg of the substance to be examined,ortheprescribedquantity, acid the tube with a stopper through which passes a smalltest-tube about 100 mm long and 10 mm in external diametercontainingwater Rto act as a condenser. On the outside ofthe smaller tube, hang a drop oflanthanum nitrate solution for substances hydrolysable only with difficulty, place theapparatus in a water-bath for 5 min, then take out the smallertube.

2.3.1. IDENTIFICATION REACTIONS OF IONS AND FUNCTIONAL GROUPS ACETATES a) Heat the substance to be examined with an equal quantity of oxalic acid R. Acid vapours with the characteristic odour of acetic acid are liberated, showing an acid reaction (2.2.4).

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