Transcription of 2.9.31. PARTICLE SIZE ANALYSIS BY LASER LIGHT DIFFRACTION
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2.9.31. PARTICLE SIZE ANALYSIS BY LASER LIGHT DIFFRACTION
european pharmacopoeia PARTICLE size ANALYSIS by LASER LIGHT DIFFRACTION the cumulative amount dissolved at each time point divided This chapter provides guidance for the measurement of size by the surface area exposed. Linear regression is then distributions of particles in different dispersed systems, for performed on the normalised experimental data relevant example, powders, sprays, aerosols, suspensions, emulsions, to an appropriate time interval preceding the possible and gas bubbles in liquids, through ANALYSIS of their angular disintegration of the compact. The intrinsic dissolution rate LIGHT -scattering patterns. It does not address specific of the substance tested, expressed in milligrams per minute requirements of PARTICLE size measurement of specific per square centimetre, is determined from the slope of the products. regression line. The result for intrinsic dissolution rate must be accompanied by a statement of the precise conditions of PRINCIPLE.
the refractive index values used, since small differences in 312 See the information section on general monographs (cover pages) EUROPEAN PHARMACOPOEIA 6.0 2.9.31.
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