Transcription of 2010 ACR/EULAR Classification Criteria for Rheumatoid ...
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2010 ACR/EULAR Classification Criteria for Rheumatoid ...
2010 ACR/EULAR Classification Criteria for Rheumatoid ArthritisPublished in the September 2010 Issues of A&Rand ARDP hases of the ProjectPhase 1 data analysisPhase 2 Consensus processPhase 3 Integration of 1 and 2 Predictors of MTX initiationFinal CriteriaDeterminants of high probability of RAIncrease feasibilityPhase 1 data Driven ApproachPhase 1: Patients and Methods Patients EARLY ARTHRITIS COHORTS 3115 patientsfrom 9 cohorts Inflammatory arthritis(no other definite diagnosis) of <3 years No previous DMARD/MTX treatment Methods PREDICTORS OF MTX TREATMENT Step 1: Univariate regression analysisof all possible variables Step 2: Principal component analysis : identify themes Step 3: Multivariate regression analysiswith all relevant themesPhase 1: Three Analytic StepsUnivariate Regression AnalysisIdentify significant variables at baselineGold standard: MTX treatment at one yearSTEP 1 Principal Component AnalysisIdentify sets of variables representing the same theme STEP 2 Multivariate regression
Data analysis Phase 2 Consensus process Phase 3 Integration of 1 and 2 Predictors of MTX initiation ... –Formal classification criteria might be a guide to establish a clinical diagnosis. Classification vs. Diagnosis Usually well defined, smaller ... fulfillment of the scoring system • The scoring result should nevertheless be
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