Transcription of 5.4 BUPROFEZIN (173) TOXICOLOGY
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5.4 BUPROFEZIN (173) TOXICOLOGY
BUPROFEZIN 101. BUPROFEZIN (173). TOXICOLOGY . BUPROFEZIN is the ISO approved name for (EZ)-2-tert-butylimino-3-isopropyl-5-phe nyl-1,3,5- thiadiazinan-4-one (IUPAC), CAS No. 69327-76-0. BUPROFEZIN is an insecticide that acts by the inhibition of chitin synthesis. BUPROFEZIN was previously evaluated by the JMPR in 1991 when an ADI of 0 mg/kg bw per day was established based on a NOAEL of mg/kg bw per day identified in a 2-year study in rats and with a safety factor of 100. The JMPR in 1999 considered that the establishment of an ARfD. was unnecessary. BUPROFEZIN was re-evaluated by the present Meeting as part of the CCPR periodic re-evaluation programme.
102 Buprofezin guinea-pigs, buprofezin gave equivocal results suggesting a very slight potential for delayed contact hypersensitivity, while the results of a local lymph-node assay with buprofezin in mice were negative.
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