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6-Hour Bundle - Surviving Sepsis Campaign | …

6-Hour Bundle 1. Apply Vasopressors (for Hypotension That Does Not Respond to Initial Fluid Resuscitation) to Maintain a Mean Arterial Pressure (MAP) 65 mm HgBackgroundAdequate fluid resuscitation is a prerequisite for the successful and appropriate use of vasopressors in patients with septic shock. In general, the end points of fluid resuscitation are the same as those for the use of pharmacologic hemodynamic support ( , MAP 65 mm Hg). Sometimes, fluid resuscitation alone may an appropriate fluid challenge fails to restore an adequate arterial pressure and organ perfusion, therapy with vasopressor agents should be started.

6-Hour Bundle Norepinephrine Norepinephrine is a potent a-adrenergic agonist with some b-adrenergic agonist effects. Norepinephrine therapy usually causes a statistically and clinically significant increase in mean

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