Transcription of A Guide for Analyzing Low-Level Total Organic …
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A Guide for Analyzing Low-Level Total Organic …
A Guide for Analyzing Low-Level Total Organic Carbon Using a UV/ Persulfate Analyzer Application Note By Stephen C. Lawson Guide to low level TOC UV/Persulfate Analysis; 11-Sep-09 Sales/Support: 800-874-2004 Main: 513-229-7000 4736 Socialville Foster Rd., Mason, OH 45040 Abstract Total Organic Carbon (TOC) analysis is a fast and efficient analytical technique that can be easily implemented in pharmaceutical manufacturing for cleaning validation due to the all-inclusive nature of the test for carbon. It can be used to test for residues of previously manufactured products, cleaning detergents, solvents, by-products, and degradants. Although the current requirement set by the pharmacopeias for instrument performance is at 500 parts per billion (ppb), many pharmaceutical companies regularly test at one-tenth and even one-hundredth that requirement.
Guide to Low Level TOC UV/Persulfate Analysis; 11-Sep-09 Sales/Support: 800-874-2004 · Main: 513-229-7000 4736 Socialville Foster Rd., Mason, OH 45040 www.teledynetekmar.com The method parameters used to generate the calibration curve are depicted in Table 1.
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