Transcription of A GUIDEBOOK TO PARTICLE SIZE ANALYSIS
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A GUIDEBOOK TO PARTICLE SIZE ANALYSIS
A GUIDEBOOK TO PARTICLE SIZE ANALYSIS TABLE OF CONTENTS 1 Why is PARTICLE size important? Which size to measure 3 Understanding and interpreting PARTICLE size distribution calculations Central values: mean, median, mode Distribution widths Technique dependence Laser diffraction Dynamic light scattering Image ANALYSIS 8 PARTICLE size result interpretation: number vs. volume distributions Transforming results 10 Setting PARTICLE size specifications Distribution basis Distribution points Including a mean value X axis Testing reproducibility Including the error Setting specifications for various ANALYSIS techniques PARTICLE Size ANALYSIS Techniques 15 LA-960 laser diffraction technique The importance of optical model Building a state of the art laser diffraction analyzer 18 LA-350 laser diffraction technique Compact optical bench and circulation pump in one system 19 ViewSizer 3000 nanotracking ANALYSIS A Breakthrough in nanoparticle tracking ANALYSIS 20 SZ-100 dynamic light scattering technique Calculating PARTICLE size Zeta Potential Molecular weight 25 PSA300 image ANALYSIS t
suspension and emulsion stability. Powder or droplets in the range of 2-5µm aerosolize better and will penetrate into lungs deeper than larger sizes. For these and many other reasons it is important to measure and control the particle size distribution of many products.
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