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A Textbook of Clinical Pharmacology and Therapeutics

A Textbook of Clinical Pharmacology and TherapeuticsThis page intentionally left blank A Textbook ofClinical Pharmacology and TherapeuticsFIFTH EDITIONJAMES M RITTERMA DPHIL FRCP FMedSciFBPHARMACOLSP rofessor of Clinical Pharmacology at King s College London School of Medicine, Guy s, King s and St Thomas Hospitals, London, UKLIONEL D LEWISMA MB BCH MD FRCPP rofessor of Medicine, Pharmacology and Toxicology at Dartmouth Medical School andthe Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USATIMOTHY GK MANTBSCFFPM FRCPS enior Medical Advisor, Quintiles, Guy's Drug Research Unit, and Visiting Professor atKing s College London School of Medicine, Guy s, King s and St Thomas Hospitals,London, UKALBERT FERROPHD FRCP FBPHARMACOLSR eader in Clinical Pharmacology and Honorary Consultant Physician at King s CollegeLondon School of Medicine, Guy s, King s and St Thomas Hospitals, London, UKPART OF HACHETTE LIVRE UKFirst published in Great Britain in 1981 Second edition 1986 Third edition 1995 Fourth edition 1999 This fifth edition published in Great Britain in 2008 byHodder Arnold, an imprint of Hodden Education, part of Hachette Livre UK,338 Euston Road, London NW1 3 2008 James M ritter , Lionel D Lewis, Timothy GK Mant and Albert FerroAll rights reserved.

A Textbook of Clinical Pharmacology and Therapeutics FIFTH EDITION JAMES M RITTER MA DPHIL FRCP FMedSci FBPHARMACOLS Professor of Clinical Pharmacology at King’s College London School of Medicine,

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