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AASLDPRACTICEGUIDELINES Diagnosis and Management …

AASLD PRACTICE GUIDELINESD iagnosis and Management of Autoimmune HepatitisMichael P. Manns,1 Albert J. Czaja,2 James D. Gorham,3 Edward L. Krawitt,4 Giorgina Mieli-Vergani,5 Diego Vergani,6and John M. Vierling7 This guideline has been approved by the AmericanAssociation for the Study of Liver Diseases (AASLD)and represents the position of the PreambleClinical practice guidelines are defined as systemati-cally developed statements to assist practitioner andpatient decisions about appropriate heath care for spe-cific clinical circumstances.

2. Introduction Autoimmune hepatitis (AIH) is a generally unresolv-ing inflammation of the liver of unknown cause. A working model for its pathogenesis postulates that environmental triggers, a failure of immune tolerance mechanisms, and a genetic predisposition collaborate to induce a T cell–mediated immune attack upon liver

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