Transcription of ACE inhibitors and ARBs: Managing potassium and renal …
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ACE inhibitors and ARBs: Managing potassium and renal …
ACE inhibitors and ARBs: Managing potassium and renal functionCLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 86 NUMBER 9 SEPTEMBER 2019 601A highly active, water- and alcohol-soluble, basic pressor substance is formed when renin and renin-activator interact, for which we suggest the name angiotonin. Irvine H. Page and O. M. Helmer, renin-angiotensin-aldosterone sys-tem regulates salt and, in part, water ho-meostasis, and therefore blood pressure and fluid balance through its actions on the heart, kid-neys, and blood Drugs that target this system angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are used primarily to treat hyperten-sion and also to treat chronic kidney disease and heart failure with reduced ejection related editorial, page 608 Controlling blood pressure is important, as hypertension increases the risk of myocardial infarction, cerebrovascular events, and pro-gression of chronic kidney disease, which itself is a risk fact
irbesartan, losartan, valsartan) Aldosterone Aldosterone antagonists (spironolactone, eplerenone) Target cells Mineralocorticoid antagonists Increased sodium absorption, potassium excretion, fluid retention Figure 1. The renin-angiotensin-aldosterone system and drugs that inhibit it.
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