Transcription of Acetaminophen 引發之腎衰竭 - tsn.org.tw
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Acetaminophen 引發之腎衰竭 - tsn.org.tw
Acetaminophen .. Acetaminophen . (1) glucuronide (2) sulfate (3). Acetaminophen (paracentamol) . (microsomal oxidation) glu- Acetaminophen . tathione ( 1) .. Acetaminophen .. glucuronide conjugation .. sulfate conjugation . 5% . Acetaminophen . (microsomal cytochrome) P-450 . Acetaminophen glutathione mer- 30 60 capturic acid [1] . 1. Acetaminophen . 92 15 1 17. Acetaminophen . glucuronide sulfate 4 6 Acetaminophen . microsomal . pathway . glutathione Acetaminophen methionine . N- acetylcysteine glutathione 1,000 IU/L . Acetaminophen . Acetaminophen PT . [1] . Acetaminophen (APAP) Acetaminophen . (deacetylation) deacetylated APAP (PAP) . 12 24 . P-450 NADPH oxygen . APBQI. electrophilic quinone . glutathione glutathione [1,4-5] . sulfhydryl group 2 7 . [2] . Acetaminophen [6] . methionine N- acetylcysteine . glutathione . aminophenol-S-conjugates . -glutamyl-trans- Acetaminophen . ferase activity [2-3] 1% 2% [5-6].
20 腎臟與透析：民國92 年15 卷1 期 N-acetylcysteine 可以減少肝毒性。Acetaminophen 引起的腎傷害主要是急性腎小管壞死，通常是可 逆的，目前並沒有特別的藥物可以使用。
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