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ACG Clinical Guideline: The Diagnosis and …

Nature publishing group PRACTICE GUIDELINES 1. ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury Naga P. Chalasani, MD, FACG1, Paul H. Hayashi, MD2, Herbert L. Bonkovsky, MD, FACG3, Victor J. Navarro, MD4, William M. Lee, MD, FACG5. and Robert J. Fontana, MD6, on behalf of the Practice Parameters Committee of the American College of Gastroenterology Idiosyncratic drug-induced liver injury (DILI) is a rare adverse drug reaction and it can lead to jaundice, liver failure, or even death. Antimicrobials and herbal and dietary supplements are among the most common therapeutic classes to cause DILI in the Western world.

The American Journal of GASTROENTEROLOGY VOLUME 104 | XXX 2014 www.amjgastro.com 2 Chalasani et al. data have begun to blur the distinction between these two catego-ries somewhat, they remain useful conceptual paradigms.

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