ACOG PRACTICE BULLETIN

E110 VOL. 130, NO. 3, SEPTEMBER 2017 OBSTETRICS & GYNECOLOGYH ereditary breast and Ovarian Cancer SyndromeHereditary breast and ovarian cancer syndrome is an inherited cancer-susceptibility syndrome characterized by mul-tiple family members with breast cancer, ovarian cancer, or both. Based on the contemporary understanding of the origins and management of ovarian cancer and for simplicity in this document, ovarian cancer also refers to fallopian tube cancer and primary peritoneal cancer. Clinical genetic testing for gene mutations allows more precise identifica-tion of those women who are at an increased risk of inherited breast cancer and ovarian cancer. For these individuals, screening and prevention strategies can be instituted to reduce their risks. Obstetrician gynecologists play an impor-tant role in the identification and management of women with hereditary breast and ovarian cancer syndrome.

risks (albeit smaller than their risk of breast and ovar-ian cancer), including prostate cancer, pancreatic can-cer, melanoma, and potentially uterine cancer (36). 35, BRCA2 mutation carriers have a threefold increased risk and up to a 7% lifetime risk of pancreatic can-cer. Additionally, BRCA2 mutation carriers have an

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