Transcription of Adverse Immune Effects of Liposomes: Complement …
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Harnessing biomaterials for Nanomedicine: Preparation, toxicity and applications Janos Szebeni & Chezy Barenholz Copyright 2009 by Pan Stanford Publishing Pte Ltd Chapter 12 Adverse Immune Effects of Liposomes: Complement Activation, Immunogenicity and Immune Suppression Janos Szebeni and Yechezkel (Chezy) Barenholz Nanomedicine Research and Education Center, Bay Zoltan Foundation for Applied Research and Semmelweis University Medical School, Budapest, and Dept of Health Sciences, Miskolc University, Hungary, and SeroScience Inc., Budapest , Laboratory of Membrane and liposome Research, Institute of Medical Research Israel Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel Some therapeutically relevant liposomes are recognized by the Immune system as foreign, and the resulting innate or specific Immune response can be Adverse to the host.
2 Adverse Immune Effects of Liposomes: Complement Activation, Immunogenicity and Immune Suppression 1. INTRODUCTION Today, 46 years after the discovery of liposomes [11], and nearly a quarter
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