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Age-Specific Reference Ranges for Prostate-Specific Antigen asa Marker for prostate CancerHans-Joachim Luboldt*, Joachim F. Schindler, Herbert Ru bbenUniversita tsklinikum, Klinik fu r Urologie, Hufeland 55, 45122 Essen, the introduction of PSA testing for prostatecancer screening there has been realized a down-ward shift from advanced incurable cancer toorgan-confined disease. Nonetheless, the diagnosticusefulness of serum PSA especially in mass screen-ing is a matter of debate. For it has been recognizedsince the early 1990s the PSA test produces up to 70%false positive results peaking in men beyond theirfifth decade of age[1]. Moreover, data fromthe European randomized study of screening foreau-ebu update series 5 (2007) 38 48available at homepage: infoKeywords: prostate cancerPSAAge- specific referenceranges for PSAE arly detectionProstate biopsyAbstractMore than a decade ago, several investigators found serum PSA levels incancer-free men to correlate directly with age and prostatic volume.
Age-Specific Reference Ranges for Prostate-Specific Antigen as a Marker for Prostate Cancer Hans-Joachim Luboldt*, Joachim F. Schindler, Herbert Ru¨bben
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