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Alcohol and Medication Interactions

Alcohol and MedicationInteractionsRon Weathermon, , and David W. Crabb, medications can interact with Alcohol , thereby altering the metabolism or effects ofalcohol and/or the Medication . Some of these Interactions can occur even at moderatedrinking levels and result in adverse health effects for the drinker. Two types of Alcohol - Medication Interactions exist: (1) pharmacokinetic Interactions , in which Alcohol interfereswith the metabolism of the Medication , and (2) pharmacodynamic Interactions , in whichalcohol enhances the effects of the Medication , particularly in the central nervous system( , sedation).

alcohol as well as other substances; some of those enzymes, including alcohol dehydrogenase (ADH) and cytochrome P450 are described in more detail in the section “Alcohol Metabolism in the Liver.” The contribution of stomach (i.e., gastric) enzymes to first-pass alcohol metabolism, however, is controversial. Whereas some researchers have pro-

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pubs.niaaa.nih.gov

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pubs.niaaa.nih.gov

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pubs.niaaa.nih.gov

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pubs.niaaa.nih.gov

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pubs.niaaa.nih.gov

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pubs.niaaa.nih.gov

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pubs.niaaa.nih.gov

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