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Alcohol and Medication Interactions

Alcohol and MedicationInteractionsRon Weathermon, , and David W. Crabb, medications can interact with Alcohol , thereby altering the metabolism or effects ofalcohol and/or the Medication . Some of these Interactions can occur even at moderatedrinking levels and result in adverse health effects for the drinker. Two types of Alcohol - Medication Interactions exist: (1) pharmacokinetic Interactions , in which Alcohol interfereswith the metabolism of the Medication , and (2) pharmacodynamic Interactions , in whichalcohol enhances the effects of the Medication , particularly in the central nervous system( , sedation). Pharmacokinetic Interactions generally occur in the liver, where both alcoholand many medications are metabolized, frequently by the same enzymes.

to alcohol-medication interactions. However, this issue still requires fur-ther investigation. Alcohol Metabolism in the Liver The liver is the primary site of alcohol metabolism. Alcohol circulating in the blood is transported to the liver, where it is broken down by several enzymes, the most important of which are ADH and cytochrome P450 ...

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