Transcription of Alcohol’s Impact on Kidney Function
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Alcohol’s Impact on Kidney Function
Cell s Function depends not only on receiving a continuous supply of nutrients and elimi-nating metabolic waste products butalso on the existence of stable physi-cal and chemical conditions in theextracellular fluid1bathing it. Amongthe most important substances con-tributing to these conditions are water,sodium, potassium, calcium, andphosphate. Loss or retention of anyone of these substances can influencethe body s handling of the others. Inaddition, hydrogen ion concentration( , acid-base balance) influencescell structure and permeability as wellas the rate of metabolic reactions. Theamounts of these substances must beheld within very narrow limits, re-gardless of the large variations possi-ble in their intake or loss.
under microscopic examination, the kidneys of alcohol-fed rats were found to have cells enlarged with increased amounts of protein, fat, and water, compared with those of the control animals. Similarly, clinicians long have noted significant kidney enlargement (i.e., nephromegaly) in direct propor-tion to liver enlargement among
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