Transcription of Alcohol’s Impact on Kidney Function
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Alcohol’s Impact on Kidney Function
Cell s Function depends not only on receiving a continuous supply of nutrients and elimi-nating metabolic waste products butalso on the existence of stable physi-cal and chemical conditions in theextracellular fluid1bathing it. Amongthe most important substances con-tributing to these conditions are water,sodium, potassium, calcium, andphosphate. Loss or retention of anyone of these substances can influencethe body s handling of the others. Inaddition, hydrogen ion concentration( , acid-base balance) influencescell structure and permeability as wellas the rate of metabolic reactions. Theamounts of these substances must beheld within very narrow limits, re-gardless of the large variations possi-ble in their intake or loss. The kidneysare the organs primarily responsiblefor regulating the amounts and con-centrations of these substances in theextracellular addition to their role in regulat-ing the body s fluid composition, thekidneys produce hormones that influ-ence a host of physiological processes,including blood pressure regulation,red blood cell production, and calciummetabolism.
2The terms “alcoholic patient ” and alcoholism as used in this article are summary terms for the diagnoses of alcohol abuse and alcohol dependence as defined variously by the studies cited. 3For a person weighing 150 pounds, this dose would be roughly equivalent to 17 drinks. Alcohol…
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