Transcription of Allogeneic Blood Transfusion Increases the Risk of ...
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Allogeneic Blood Transfusion Increases the Risk ofPostoperative Bacterial Infection: A Meta-analysisGary E. Hill, MD, William H. Frawley, PhD, Karl E. Griffith, MD, John E. Forestner, MD, andJoseph P. Minei, MDBackground:Immunosuppression isa consequence of Allogeneic (homologous) Blood Transfusion (ABT) in humans and isassociated with an increased risk in cancerrecurrence rates after potentially curativesurgery as well as an increase in the fre-quency of postoperative bacterial infec-tions. Although a meta- analysis has beenreported demonstrating the relationshipbetween ABT and colon cancer recur-rence, no meta- analysis has been reporteddemonstrating the relationship of ABT topostoperative bacterial :Twenty peer-reviewed arti-cles published from 1986 to 2000 were in-cluded in a meta- analysis . Criteria for inclu-sion included a clearly defined controlgroup (nontransfused) compared with atreated (transfused) group and statisticalanalysis of accumulated data that includedstepwise multivariate logistic regressionanalysis.
Allogeneic Blood Transfusion Increases the Risk of Postoperative Bacterial Infection: A Meta-analysis Gary E. Hill, MD, William H. Frawley, PhD, Karl E. Griffith, MD, John E. Forestner, MD, and
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