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Alnylam Forward Looking Statements

1 2022 Alnylam Pharmaceuticals, 2022 Alnylam PharmaceuticalsNathan (USA)Diagnosed with AHP2 Alnylam Forward Looking StatementsThispresentationcontainsforwar d-lookingstatementswithinthemeaningofSec tion27 AoftheSecuritiesActof1933andSection21 EoftheSecuritiesExchangeActof1934,includ ingexpectationsregardingouraspirationtob ecomealeadingbiotechcompanyandtheplanned achievementofour AlnylamP5x25 strategy,ourabilitytoattainfinancialself -sustainability,ourpreliminaryfourthquar terand2021fiscalyearglobalnetproductreve nueandpatientsontherapy,theprobabilityof successofourRNAitherapeuticsplatform.

Notable Accomplishments in 2021 * Preliminary selected financial results are unaudited, subject to adjustment, and provided as an approximation in advance of the Company’s announcement of complete financial results in February 2022. 2 NDA/sNDA submissions (vutrisiran, OXLUMO®) Completed enrollment in two key Phase 3 studies in ATTR-CM

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