Alpha1-Fetoprotein (AFP) Reference Values in …

ALPHA,- fetoprotein (AFP) Reference Values IN INFANTS UP TO 2 YEARS OF AGE M. E. C. Blohm, MD, D. Vesterling-Horner, MD, C. Calaminus, MD, and U. Gobel, MD Department of Paediatric Haematology and Oncology, Children s Hospital, Heinrich Heine University Medical Centre, Dussrldorf, Germany The azm of thzc tludy wac to pstablzsh Reference Values andjktorr atsocaated wzth smm AFP rlevatzon in znfantc Fzve hundrrd twentyfour samples collerkd from infants up to the age of 2 years at the Unzversity Hospzlal DUSSQ~~O$ (Germany) were analyzpd At birth mean cmm AFP levels were 41,687 ng/ml zn 256 term Oabzes and 158,125 ng/ml zn 90 premature babzrc born before the 37th geslalzonal week, excludzng samples from chzldren wzth factors known to b~ ass@ czatrd utzth AFP elp(m/taon. In thpjirst 4 weeks oflzfr, AFP hrls derreated by 50% in dqr zn tprm babzrc Betwpen day 180 and 720 oflfe, AFP levels up to 87 ng/ml were iuzthzn the % zrilerual (acsumed loganthmzr normal dzstnbutzon) wzth a mean of 8 ng/ml wzthout n further derlzne Bj the agp of 2 yearc the znfantc of thzs study had not reached adult smm AFP helc (0-6 ng/W Keywords alpha ,- fetoprotein , infants, Reference Values Alpha,- fetoprotein (AFP) is a glycoprotein consisting of 590 amino ac- ids [l))]

136 M. E. C. BLOHM El AL. tional week [13]; maternal serum AFP levels are highest in the 32nd gesta- tional week. Fetal levels subsequently fall to the range of 17,200-44,350

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  Reference, Value, Maternal, Serum, Alpha1 fetoprotein, Alpha1, Fetoprotein, Reference values in, Maternal serum

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