Transcription of American Thoracic Society Documents
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American Thoracic Society Documents
American Thoracic Society DocumentsAn Official American Thoracic Society Statement:Treatment of Fungal Infections in Adult Pulmonaryand Critical Care PatientsAndrew H. Limper, Kenneth S. Knox, George A. Sarosi, Neil M. Ampel, John E. Bennett, Antonino Catanzaro,Scott F. Davies, William E. Dismukes, Chadi A. Hage, Kieren A. Marr, Christopher H. Mody, John R. Perfect,and David A. Stevens, on behalf of the American Thoracic Society Fungal Working GroupTHISOFFICIALSTATEMENT OF THEAMERICANTHORACICSOCIETY(ATS)WAS APPROVED BY THEATS BOARDOFDIRECTORS,MAY2010 CONTENTSI ntroductionMethodsAntifungal Agents: General ConsiderationsPolyenesTriazolesEchinocan dinsTreatment of Fungal InfectionsHistoplasmosisSporotrichosisBl astomycosisCoccidioidomycosisParacoccidi oidomycosisCryptococcosisAspergillosisCa ndidiasisPneumocystis PneumoniaTreatment of Other FungiGlossary of TermsWith increasing numbers of immune-compromised patients withmalignancy,hematologicdisease,andHIV ,aswellasthosereceivingimmunosupressive drug regimens for the management of organtransplantation or autoimmune inflammatory conditions, the in-cidence of fungal infections has dramatically increased over recentyears.
most effective for ameliorating the severe rigors. Rapid in-travenous administration of amphotericin B has been observed to precipitate life-threatening hyperkalemia and arrhythmias (5); therefore, the daily dose of amphotericin B deoxycholate should be infused over 2 to 6 hours. Hypotension and shock
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