Transcription of Amino Acid-Protecting Groups
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Amino Acid-Protecting Groups
1 Amino Acid-Protecting Groups Albert Isidro-Llobet,1 Mercedes lvarez,1,2,3* Fernando Albericio1,2,4* 1 Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. 2 CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. 3 Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain. 4 Department of Organic Chemistry, University of Barcelona, Mart i Franqu s 1, 08028-Barcelona, Spain. E-mail: RECEIVED DATE *Authors to whom correspondence should be addressed. Fax: 34 93 403 71 26. E-mail: Create PDF files without this message by purchasing novaPDF printer ( ) 2 Contents 1. Introduction 4 2. - Amino 5 General 5 Introduction of the protecting Groups 5 Removal 7 protecting Groups removed by acid 7 protecting Groups removed by base 11 Other protecting Groups 17 3.
the concept of orthogonality, in the sense that the two or more protecting groups belong to independent classes and are removed by distinct mechanisms. The groups can be removed
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