Transcription of Amino Acid-Protecting Groups
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Amino Acid-Protecting Groups
1 Amino Acid-Protecting Groups Albert Isidro-Llobet,1 Mercedes lvarez,1,2,3* Fernando Albericio1,2,4* 1 Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. 2 CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. 3 Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain. 4 Department of Organic Chemistry, University of Barcelona, Mart i Franqu s 1, 08028-Barcelona, Spain. E-mail: RECEIVED DATE *Authors to whom correspondence should be addressed.
protecting groups, when the peptide is to be coupled at its C-terminus) or even the peptidic chain. The α-amino-protecting group should confer solubility in the most common solvents and prevent or minimize epimerization during the coupling, and its removal should be fast, efficient, free of side reactions and should render easily eliminated by ...
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