Transcription of Amino Acid-Protecting Groups
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Amino Acid-Protecting Groups
1 Amino Acid-Protecting Groups Albert Isidro-Llobet,1 Mercedes lvarez,1,2,3* Fernando Albericio1,2,4* 1 Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. 2 CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. 3 Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain. 4 Department of Organic Chemistry, University of Barcelona, Mart i Franqu s 1, 08028-Barcelona, Spain. E-mail: RECEIVED DATE *Authors to whom correspondence should be addressed. Fax: 34 93 403 71 26. E-mail: Create PDF files without this message by purchasing novaPDF printer ( ) 2 Contents 1.
2. α-AMINO 2.1 General Protection of the α-amino functionality of amino acids is one of the most important issues in peptide chemistry and is mandatory to prevent polymerization of the amino acid once it is activated. As most peptide syntheses, both in solution and on solid phase, are carried out in the C to N
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