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Analysis of Residual Solvents using GC/FID with …

Analysis of Residual Solvents using GC/FIDwith headspace and a Cyanopropylphenyl Polysiloxane PhaseA. Khan, L. Pereira, Thermo Fisher Scientific, Runcorn, Cheshire, UKOverviewA Thermo Scientific TRACE Ultra GC system with aThermo Scientific TriPlus Autosampler was used for theanalysis of Residual Solvents in accordance with USPmethod column used for the Analysis was aThermo Scientific TRACE TR-V1 This application note describes the Analysis of Residual Solvents according to the revised (effective July 2007) USPharmacopeia (USP) method. The method is used for analyzing trace levels of Solvents that are involved in theproduction of a drug, excipient or product packaging in thepharmaceutical industry. Drug products should contain lowlevels of Residual Solvents as determined by safety data.

Analysis of Residual Solvents using GC/FID with Headspace and a Cyanopropylphenyl Polysiloxane Phase A. Khan, L. Pereira, Thermo Fisher Scientific, Runcorn, Cheshire, UK

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