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Antibiotic Prophylaxis Why the new guidelines?

Antibiotic Prophylaxis Why the new guidelines ?Babak Bina of General Practice ResidencyLutheran Medical CenterBrooklynAntibiotic ProphylaxisA. Cardiac conditionsB. Intravascular ProsthesisC. Prosthetic JointsD. Hemodialysis E. CAPDF. TransplantG. NeutropeniaCardiac ConditionsAntibiotic Prophylaxis is being used to avoid infection of the heart valve and/ or endothelial surfaces of the heart. (Bacterial Endocarditis)Cardiac ConditionsEffects of Bacterial Endocarditis- Local complications- Embolic complications- Immune complex mediated complicationCardiac Conditions Local complications:Valvular Insufficiency, CHFM yocardial AbscessesCardiac Conditions Embolic complications:- Skin - Eyes- Brain- Liver- Spleen- Kidney- IntestineCardiac Conditions Immune complex mediated complications:- Arthritis- GlumeronephritisCardiac Conditions Extremely rare A concern in patients with Pre-existing conditions 7- 10 % mortality and severe morbidity Treatment: Aggressive Antibiotic and surgical therapyCardiac Conditions Incidence of SBE2-5/ 100,00 in general population20/ 100,000 Bicuspid Aortic Valve25/ 100,000 MVP w/o Regurgitation56/ 100,000 MVP with Regurgitation220/ 100,000 Ventricular Septal Defect10,000/ 100,000 Previous history of one SBE25,000/ 100,000 Previous history of two SBEC ardiac Conditions 30 40 % of patients with SBE have streptococcal infections S.

Cardiac Conditions Antibiotic prophylaxis is being used to avoid infection of the heart valve and/ or endothelial surfaces of the heart. (Bacterial Endocarditis)

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