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Antidepressants Comparison Guide Recommend Most …

Adverse EffectsClassGeneric (Brand)Average 30-Day Supply Cost to Health Alliance/CarleFDA-Labeled Indications and Usual or Target Adult Daily Dosage RangeAnticholinergicDrowsinessOrthostati c HypotensionQtc ProlongationWeight GainCYP450 MetabolismCommentsSerotonin Specific Reuptake Inhibitors (SSRIs)Citalopram (Celexa)$2 MDD: 20-40mg daily--+++Yes. Dosage adjustments may be required. Consult monograph for specific 20mg daily with hepatic (Lexapro)$5 MDD: 10-20mg dailyGAD: 10-20mg daily--+++Yes. Dosage adjustments may be required. Consult monograph for specific 10mg daily with hepatic (Prozac)$15 Bipolar depression (in combination with olanzapine): 20-60mgBulimia nervosa: 20-60mg dailyMDD: 20-80mg daily OCD: 40-80mg dailyPanic disorder: 10-60mg daily--+++Yes.

venlafaxine Stop SSRI and start venlafaxine at a low dose (e.g., 37.5 mg to 75 mg total daily dose). If the patient was taking a high dose of an SSRI, consider tapering to a lower dose before stopping it and starting venlafaxine. Cautious cross-taper, starting with low dose of venlafaxine, is another option. If switching from fluvoxamine, cross-

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