Transcription of Antisense Treatment for Myasthenia Gravis - …
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Antisense Treatment for Myasthenia Gravis - …
Antisense Treatment for Myasthenia Gravis Experience with Monarsen JON D. SUSSMAN,a ZOHAR ARGOV,b DAVID MCKEE,a ELI HAZUM,c SOLLI BRAWER,c AND HERMONA SOREQ b a Department of Neurology, Greater Manchester Neuroscience Centre, Hope Hospital, Salford, United Kingdom b Department of Neurology, Hadassah-Hebrew University Medical Centre, Hebrew University, Jerusalem, Israel c Ester Neurosciences Ltd., Herzlia, Israel Acetylcholinesterase pre-mRNA is susceptible to alternative splicing. Myasthenia Gravis has been shown to be associated with the expression of the readthrough transcript (AChE-R), which, unlike the normal synaptic transcript (AChE-S) is not tethered to the post-synaptic membrane, but is a soluble monomer in the synaptic cleft.
Antisense Treatment for Myasthenia Gravis Experience with Monarsen JON D. SUSSMAN,a ZOHAR ARGOV,b DAVID MCKEE,a ELI HAZUM,c SOLLI BRAWER,c AND HERMONA SOREQb aDepartment of Neurology, Greater Manchester Neuroscience Centre, Hope Hospital,
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