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Apheresis: Basic Principles, Practical Considerations and ...

Apheresis: Basic Principles, Practical Considerations and Clinical ApplicationsJoseph Schwartz, MD Director, Transfusion Medicine Columbia Univ. Medical CenterNew York Presbyterian Hospital Anand Padmanabhan, MD PhDAssoc Med Director/Asst ProfBloodCenter of WisconsinMedical College of WisconsinReview Session, ASFA Annual meeting, Scottsdale, Arizona, June 2011 Objectives (Part 1) Mechanism of Action Definitions Technology (ies) Use Practical Considerations Math Clinical applications HPC Collection Clinical applications: System/Disease Specific Indications ASFA Fact SheetObjectives (Part 2) Apheresis Derives from Greek, to carry away A technique in which whole blood is taken and separated extracorporealy, separating the portion desired from the remaining blood.

•Calculate treatment dose •TPE and RBC Exchange replacement fluid volumes •Cytoreduction and PBSC collections •Determine patient tolerance/safety Calculating % of extracorpreal volume - The amount of blood outside the patient’s body at any given time - Should not exceed 15% of patient's total estimated blood volume

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