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API Synthesis and Formulation - …

2009 Supplement to the September 2009 IssueAPI Synthesis and FormulationEUROPEDrug deliveryrug development is an arduous, financially risky pro-cess that has been estimated to cost pharmaceutical firms an average of $802 million for each therapeutic gaining marketing approval (1). To maximize return on the initial investment, companies look to strengthen their market position and extend product life cycles through reformulations, new routes of administration, and use of the latest technology. For injectable therapeutics, one way to accomplish this goal is to move a product s presentation from a vial to a prefilled sy-ringe.

delivery devices also judge the ease of self-administration (37%) and whether the product has been recommended by the physician (24%) (4). Prefilled syringes also present economic advantages for

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