Transcription of APOMINE™ INJECTION - Medsafe
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APOMINE™ INJECTION - Medsafe
Data Sheet New Zealand 1 Version . apomine INJECTION NAME apomine In jection DESCRIPTION apomine In jection is a sterile soluti on containing 10 mg/m L of apomorphine hydrochloride in Water for In jections . Sodium metabisulfit e 1 mg/mL is included in the formulati on as an antioxidant. The pH of the INJECTION is to The CAS registry number of apomorphine hydrochloride, anhydrous is 41372-20-7 and th e chemical structure is shown below: HO HO H HCl Me N PHARMACOLOGY Apomorphine is a directl y acti ng dopamine receptor agonist, structurally related to dopamine. Apomorphine has high in vitr o binding affinity for the dopamine D4 and D5 receptor (Ki:4 and 14 nM respecti vely), moderate affinity (Ki: 26 to 130 nM) for the dopamine D2 and D3, adre nergic 1D, 2B, 2C recepto rs, serotonin 5HT1A, 5HT2A, 5HT2B , and 5HT2C receptors and low affi nity for the dopamine D1 recepto r (Ki: 370 nM).
Apomine™ Injection is indicated to reduce the number and severity of ‘off’ phases in patients with Parkinson’s Disease severely disabled by motor fluctuations refractory to conventional therapy.
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