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Appendix I FACTT Algorithm: Composite Protocol-Version 2

algorithm Version 2, rev. 10/12/2000 NOTE: numbers in upper right hand corner of each cell = cell numbers; superscripts refer to footnotes that may modify Study Version IIARDSNet Study 05 Appendix I FACTT algorithm : Composite Protocol-Version 2 Intravascular PressureMAP 60 mm Hg AND off vasopressors(Dopamine 5 mcg/kg/min is not a vasopressor)CVPPAOPGA verage UOP < ml/kg/hrAverage UOP ml/kg/hrConservativeLiberalConservativeLiberalMAP< 60 mm Hgor on:dopamine >5mcg/kg/min orany dose causesof shock < & mottledwith capillary refill >2 ofineffectivecirculation < Cold & mottledwith capillary refill> 2 OR Absence ofineffective circulationcriteriaRange I> 13> 18> 18> 24 KVO ,2,4 KVO ,2,4 KVO ,3,4 KVO IV ,3,4 Range II9-1315-1813-1819-24 1 VasopressorFFluid bolusFKVO IV4 DobutamineAKVO ,2,4 KVO IV12 DobutamineAKVO IV ,3,4 Range IIIL iberal: 17 KVO IV4-810-148-1214-18 Fluid bolusC5 Fluid bolusC9 Flu

Algorithm Version 2, rev. 10/12/2000 NOTE: numbers in upper right hand corner of each cell = cell numbers; superscripts refer to footnotes that may modify instructions. FACTT Study Version II ARDSNet Study 05 Appendix I FACTT Algorithm: Composite Protocol-Version 2Intravascular Pressure

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