Approach to Patients with Elevated AFP without …

Approach to Patients with Elevated AFP without Liver MassCesar Yaghi MDHotel Dieu de FranceUniversit Saint Fetoprotein in HCC Levels greater than 500 mcg/L (normal in most laboratories is between 10 and 20 mcg/L) in a high-risk patient is diagnostic of HCC HCC is often diagnosed at a lower AFP level in Patients undergoing screening Not all tumors secrete AFP, and serum concentrations are normal in up to 40 percent of small HCCs AFP levels are normal in the majority of Patients with fibrolamellarcarcinomaAFP CutoffSensitivitySpecificity16 mcg/L 62%89 %20 mcg/L 60%91 %100 mcg/L 31%99 %200 mcg/L 22%99 %Conditions Associated with Increased Alpha Fetoprotein levelsLiver Related HCC Chronic liver disease without HCC may be slightly higher in Patients with cirrhosis due to hepatitis C In one report, serum AFP decreased significantly in Patients with cirrhosis from hepatitis C, treated with peginterferon plus ribavirin Acute hepatitis Acute Liver Failure in regenerative phaseOther Conditions Pregnancy Prenatal screening and diagnosis of neural tube defects abdominal wall defects (Beckwith-Wiedemannsyndrome)

Approach to Patients with Elevated AFP without Liver Mass Cesar YaghiMD Hotel Dieude France UniversitéSaint Joseph cesar.yaghi@usj.edu.lb

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